Single metallic nanoparticle imaging for protein detection in cells

Details Single metallic nanoparticle imaging for protein detection in cells Single metallic nanoparticle imaging for protein detection in cells

2007-04-28

arxiv.org/abs/0704.3816v1

Proceeding of the national academy of sciences 100, 20 (30/09/2003) 11350

Physics

Optics

Scientific paper

10.1073/pnas.1534635100

We performed a visualization of membrane proteins labeled with 10-nm gold nanoparticles in cells, using an all-optical method based on photothermal interference contrast. The high sensitivity of the method and the stability of the signals allows 3D imaging of individual nanoparticles without the drawbacks of photobleaching and blinking inherent to fluorescent markers. A simple analytical model is derived to account for the measurements of the signal amplitude and the spatial resolution. The photothermal interference contrast method provides an efficient, reproducible, and promising way to visualize low amounts of proteins in cells by optical means.

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