Single cell mechanics: stress stiffening and kinematic hardening

Details Single cell mechanics: stress stiffening and kinematic hardening Single cell mechanics: stress stiffening and kinematic hardening

2007-06-26

arxiv.org/abs/0706.3883v2

Physics

Biological Physics

4 pages, 6 figures

Scientific paper

10.1103/PhysRevLett.100.238102

Cell mechanical properties are fundamental to the organism but remain poorly understood. We report a comprehensive phenomenological framework for the nonlinear rheology of single fibroblast cells: a superposition of elastic stiffening and viscoplastic kinematic hardening. Our results show, that in spite of cell complexity its mechanical properties can be cast into simple, well-defined rules, which provide mechanical cell strength and robustness via control of crosslink slippage.

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