Physics – Biological Physics
Scientific paper
2002-07-27
Physics
Biological Physics
16 pages, 1 figure, Accepted for publication in Phys. Rev. E
Scientific paper
10.1103/PhysRevE.66.031913
By using the Jensen-Shannon divergence, genomic DNA can be divided into compositionally distinct domains through a standard recursive segmentation procedure. Each domain, while significantly different from its neighbours, may however share compositional similarity with one or more distant (non--neighbouring) domains. We thus obtain a coarse--grained description of the given DNA string in terms of a smaller set of distinct domain labels. This yields a minimal domain description of a given DNA sequence, significantly reducing its organizational complexity. This procedure gives a new means of evaluating genomic complexity as one examines organisms ranging from bacteria to human. The mosaic organization of DNA sequences could have originated from the insertion of fragments of one genome (the parasite) inside another (the host), and we present numerical experiments that are suggestive of this scenario.
Azad Rajeev K.
Li Wentian
Ramaswamy Ramakrishna
Rao Subba J.
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