Significance analysis and statistical mechanics: an application to clustering

Details Significance analysis and statistical mechanics: an application to clustering Significance analysis and statistical mechanics: an application to clustering

2010-09-13

arxiv.org/abs/1009.2470v1

Biology

Quantitative Biology

Molecular Networks

to appear in Phys. Rev. Lett

Scientific paper

This paper addresses the statistical significance of structures in random data: Given a set of vectors and a measure of mutual similarity, how likely does a subset of these vectors form a cluster with enhanced similarity among its elements? The computation of this cluster p-value for randomly distributed vectors is mapped onto a well-defined problem of statistical mechanics. We solve this problem analytically, establishing a connection between the physics of quenched disorder and multiple testing statistics in clustering and related problems. In an application to gene expression data, we find a remarkable link between the statistical significance of a cluster and the functional relationships between its genes.

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