Biology – Quantitative Biology – Molecular Networks
Scientific paper
2005-09-14
PLoS Comput Biol. 2006 Jan;2(1):e3. Epub 2006 Jan 27.
Biology
Quantitative Biology
Molecular Networks
33 pages, 7 figures
Scientific paper
10.1371/journal.pcbi.0020003
The TGF-beta pathway plays a central role in tissue homeostasis and morphogenesis. It transduces a variety of extracellular signals into intracellular transcriptional responses that control a plethora of cellular processes, including cell growth, apoptosis, and differentiation. We use computational modeling to show that coupling of signaling with receptor trafficking results in a highly versatile signal-processing unit, able to sense by itself absolute levels of ligand, temporal changes in ligand concentration, and ratios of multiple ligands. This coupling controls whether the response of the receptor module is transient or permanent and whether or not different signaling channels behave independently of each other. Our computational approach unifies seemingly disparate experimental observations and suggests specific changes in receptor trafficking patterns that can lead to phenotypes that favor tumor progression.
Jansen Ronald
Sander Chris
Vilar Jose M. G.
No associations
LandOfFree
Signal processing in the TGF-beta superfamily ligand-receptor network does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Signal processing in the TGF-beta superfamily ligand-receptor network, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Signal processing in the TGF-beta superfamily ligand-receptor network will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-680603