Biology – Quantitative Biology – Molecular Networks
Scientific paper
2008-05-29
Biology
Quantitative Biology
Molecular Networks
16 pages. Acknowledgement is corrected
Scientific paper
In this work we focus on how noise propagates in biochemical reaction networks and affects sensitivities of the system. We discover that the stochastic fluctuations can enhance sensitivities in one region of the value of control parameters by reducing sensitivities in another region. Based on this compensation principle, we designed a concentration detector in which enhanced amplification is achieved by an incoherent feedforward reaction network.
Kim Kyung Hyuk
Qian Hong
Sauro Herbert M.
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