Physics
Scientific paper
Dec 2011
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2011oleb...41..563b&link_type=abstract
Origins of Life and Evolution of Biospheres, Volume 41, Issue 6, pp.563-567
Physics
Prebiotic Peptides, Self-Replication, Β-Sheets
Scientific paper
Most self-replicating peptide systems are made of α-helix forming sequences. However, it has been postulated that shorter and simpler peptides may also serve as templates for replication when arranged into well-defined structures. We describe here the design and characterization of new peptides that form soluble β-sheet aggregates that serve to significantly accelerate their ligation and self-replication. We then discuss the relevance of these phenomena to early molecular evolution, in light of additional functionality associated with β-sheet assemblies.
Ashkenasy Gonen
Ashkenasy Nurit
Bourbo Valery
Matmor Maayan
Rubinov Boris
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