Physics – Medical Physics
Scientific paper
Jan 2000
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2000aipc..504..218m&link_type=abstract
SPACE TECHNOLOGY AND APPLICATIONS INTERNATIONAL FORUM - 2000. AIP Conference Proceedings, Volume 504, pp. 218-223 (2000).
Physics
Medical Physics
1
Spaceborne And Space Research Instruments, Apparatus, And Components, Aerospace Bio- And Medical Physics, Proteins
Scientific paper
Past studies have shown that both hypo- and hyper-gravity have significant consequences on a variety of tissues and organ systems. It is not known if the effects of environmental stimuli such as altered gravity are beneficial or detrimental, and if the effects can be prevented or reversed. Animal experiments from the Space Lab and Cosmos missions indicate that events that are mediated by cyclic AMP, such as cellular responses to catecholamine and peptide hormone action, are significantly altered in a number of tissues as a consequence of space flight. A secretory cyclic AMP-receptor protein (cARP), is present in saliva, and can serve as an indicator of individual responses to physiologic and environmental stress. Animal experiments have shown that the hypergravity component of space flight is a significant stress factor. In humans, cARP levels in each individual are constant under normal conditions, but elevated after acute stress. Additionally, the levels of cARP in secreted saliva can be compared to those in gingival crevicular fluid (GCF), which reflects the protein composition of serum. The ratio of cARP in saliva to that in GCF can be used as a measure of basal compared to hyper-or hypo-gravity values. An ultimate goal is to test hyper and zero G responses in human saliva to determine if cARP is a suitable index of acute and chronic stress. A miniaturized test kit for saliva collection has been designed. Samples can be collected and stored till analyses are carried out that will distinguish the effects of increased gravity from those of one and zero G. Such tests can serve as an individualized monitoring system for physiologic responses either in space or on earth. .
Burke Christopher J.
Grindeland R. E.
Hand A. R.
Mednieks M. I.
Sivakumar T. P.
No associations
LandOfFree
Secretory proteins characteristic of environmental changes in cellular signal transduction: Expression in oral fluid does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Secretory proteins characteristic of environmental changes in cellular signal transduction: Expression in oral fluid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Secretory proteins characteristic of environmental changes in cellular signal transduction: Expression in oral fluid will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-1252428