Second harmonic optical coherence tomography

Details Second harmonic optical coherence tomography Second harmonic optical coherence tomography

2004-02-12

arxiv.org/abs/physics/0402060v1

Physics

Optics

3 pages, 5 figures. Submitted on November 8, 2003, this paper has recently been accepted by Optics Letters

Scientific paper

10.1364/OL.29.001090

Second harmonic optical coherence tomography, which uses coherence gating of second-order nonlinear optical response of biological tissues for imaging, is described and demonstrated. Femtosecond laser pulses were used to excite second harmonic waves from collagen harvested from rat tail tendon and a reference nonlinear crystal. Second harmonic interference fringe signals were detected and used for image construction. Because of the strong dependence of second harmonic generation on molecular and tissue structures, this technique offers contrast and resolution enhancement to conventional optical coherence tomography.

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