Role of ATP-hydrolysis in the dynamics of a single actin filament

Details Role of ATP-hydrolysis in the dynamics of a single actin filament Role of ATP-hydrolysis in the dynamics of a single actin filament

2009-08-05

arxiv.org/abs/0908.0657v2

Biophys. J, 98, 1418 (2010)

Biology

Quantitative Biology

Biomolecules

To appear in Biophysical Journal (2010)

Scientific paper

We study the stochastic dynamics of growth and shrinkage of single actin filaments taking into account insertion, removal, and ATP hydrolysis of subunits either according to the vectorial mechanism or to the random mechanism. In a previous work, we developed a model for a single actin or microtubule filament where hydrolysis occurred according to the vectorial mechanism: the filament could grow only from one end, and was in contact with a reservoir of monomers. Here we extend this approach in several ways, by including the dynamics of both ends and by comparing two possible mechanisms of ATP hydrolysis. Our emphasis is mainly on two possible limiting models for the mechanism of hydrolysis within a single filament, namely the vectorial or the random model. We propose a set of experiments to test the nature of the precise mechanism of hydrolysis within actin filaments.

Affiliated with

Also associated with

No associations

Rating

Role of ATP-hydrolysis in the dynamics of a single actin filament does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Role of ATP-hydrolysis in the dynamics of a single actin filament, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Role of ATP-hydrolysis in the dynamics of a single actin filament will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-254779