Robustness in Gene Circuits: Clustering of Functional Responses

Details Robustness in Gene Circuits: Clustering of Functional Responses Robustness in Gene Circuits: Clustering of Functional Responses

2005-03-01

arxiv.org/abs/q-bio/0503005v1

Biology

Quantitative Biology

Molecular Networks

6 pages, 7 figures, American Control Conference 2005

Scientific paper

In contrast to engineering applications, in which the structure of control laws are designed to satisfy prescribed function requirements, in biology it is often necessary to infer gene-circuit function from incomplete data on gene-circuit structure. By using the feed-forward loop as a model system, this paper introduces a technique for classifying gene-circuit function given gene-circuit structure. In simulations performed on a comprehensive set of models that span a broad range of parameter space, some designs are robust, producing one unique type of functional response regardless of parameter selection. Other designs may exhibit a variety of functional responses, depending upon parameter values. We conclude that, although some feed-forward loop models have designs that lend themselves to unique function inference, others have designs for which the function type may be uncertain.

Affiliated with

Also associated with

No associations

Rating

Robustness in Gene Circuits: Clustering of Functional Responses does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Robustness in Gene Circuits: Clustering of Functional Responses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Robustness in Gene Circuits: Clustering of Functional Responses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-284255