Biology – Quantitative Biology – Molecular Networks
Scientific paper
2007-02-28
Biology
Quantitative Biology
Molecular Networks
presented at CompBioNets, dec 2004, recife, Brazil
Scientific paper
10.1103/PhysRevE.76.011917
We study the dynamics of gene activities in relatively small size biological networks (up to a few tens of nodes), e.g. the activities of cell-cycle proteins during the mitotic cell-cycle progression. Using the framework of deterministic discrete dynamical models, we characterize the dynamical modifications in response to structural perturbations in the network connectivities. In particular, we focus on how perturbations affect the set of fixed points and sizes of the basins of attraction. Our approach uses two analytical measures: the basin entropy $H$ and the perturbation size $\Delta$, a quantity that reflects the distance between the set of fixed points of the perturbed network to that of the unperturbed network. Applying our approach to the yeast-cell cycle network introduced by Li \textit{et al.} provides a low dimensional and informative fingerprint of network behavior under large classes of perturbations. We identify interactions that are crucial for proper network function, and also pinpoints functionally redundant network connections. Selected perturbations exemplify the breadth of dynamical responses in this cell-cycle model.
Naef Felix
Rougemont Jacques
Stoll Gautier
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