Refining the Protein-Protein Interactome using Gene Expression Data

Details Refining the Protein-Protein Interactome using Gene Expression Data Refining the Protein-Protein Interactome using Gene Expression Data

2010-03-14

arxiv.org/abs/1003.2811v1

Biology

Quantitative Biology

Molecular Networks

Scientific paper

Proteins interact with other proteins within biological pathways, forming connected subgraphs in the protein-protein interactome (PPI). However, proteins are often involved in multiple biological pathways which complicates inference about interactions between proteins. Gene expression data is informative here since genes within a particular pathway tend to have more correlated expression patterns than genes from distinct pathways. We provide an algorithm that uses gene expression information to remove inter-pathway protein-protein interactions, thereby simplifying the structure of the protein-protein interactome. This refined topology permits easier interpretation of multiple biological pathways simultaneously.

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