Physics – Medical Physics
Scientific paper
Jun 2008
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2008apsp.conf..640d&link_type=abstract
ASTROPARTICLE, PARTICLE AND SPACE PHYSICS, DETECTORS AND MEDICAL PHYSICS APPLICATIONS. Proceedings of the 10th Conference. Held
Physics
Medical Physics
Scientific paper
We present an X-ray μ-radiographic system developed for dynamic high spatial resolution imaging of living small animals. Our system is based on a micro-focus X-ray tube and the hybrid single photon counting silicon pixel detector Medipix2 (matrix 256 × 256 sq. pixels of 55 μm pitch). As soft tissue exhibits low contrast in classical absorption radiography, we exploit a new method of phase-enhanced imaging. Picture quality is further improved by statistical data analysis and extended calibration of individual pixel's response. Computing tomography provides 3D images of studied samples from radiographic projections. For 3D reconstruction of measured objects we use iterative algorithms which are advantageous for low statistics data, low or incomplete number of projections and complex physical model. This diagnostic system allows real-time observation of inner processes in living organisms and dynamic diagnose of living animals for biological studies. The obtained results and real-time stream video capability is demonstrated on samples of a mouse and living worm, caterpillar, etc.
Dammer Jiri
Hanus Robert
Holy Tomas
Jakubek Jan
Jakubek Martin
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