Physics – Medical Physics
Scientific paper
2011-11-29
Physics
Medical Physics
+In memory of W. Duechting, who departed in December, 2010
Scientific paper
Using 31P-NMR spectroscopy the chronological behavior of the ATP-metabolism of the tumor spheroids C3H-MA, 9L-Gliome and the mono-layer L1210 has been analyzed via decrease of the {\beta}-peak. All three cell lines show characteristic periods, and a homeostatic control cannot be recognized. Essential components of these periods are circadian (i.e. one day), circa-semiseptan (i.e. 3.5 days) and circa-septan (i.e. one week). The determination of the survival fractions provides an optimum exploitation of radiation damages, when the ATP-concentration assumes a maximum value. This optimum is reached, when all three cycles exhibit the ATP maximum, which is only possible by accounting for the circa-septan rhythm. The goal of this study is to elaborate an optimal fractionation scheme with regard to the irradiation of tumors.
No associations
LandOfFree
Radiobiological investigations at tumor cell lines by exploiting chrono-biological aspects of chronological dose distributions does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Radiobiological investigations at tumor cell lines by exploiting chrono-biological aspects of chronological dose distributions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Radiobiological investigations at tumor cell lines by exploiting chrono-biological aspects of chronological dose distributions will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-16471