Radiation Interaction with Therapeutic Drugs and Cell Membranes

Details Radiation Interaction with Therapeutic Drugs and Cell Membranes Radiation Interaction with Therapeutic Drugs and Cell Membranes

Apr 2007

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007aipc..899..816m&link_type=abstract

SIXTH INTERNATIONAL CONFERENCE OF THE BALKAN PHYSICAL UNION. AIP Conference Proceedings, Volume 899, pp. 816-816 (2007).

Physics

Ionizing Radiations, Radio Frequency And Microwave Radiation, Active Transport Processes, Ion Channels, Membranes, Bilayers, And Vesicles

Scientific paper

This transient permeabilized state of the cell membrane, named the ``cell electroporation'' (CE) can be used to increase cells uptake of drugs that do not readily pass cell membrane, thus enabling their cytotoxicity. The anticancer drugs, such as bleomycin (BL) and cisplatin, are the most candidates for the combined use with ionizing and non-ionizing radiation fields. The methods and installations for the cell electroporation by electron beam (EB) and microwave (MW) irradiation are presented. The viability tests of the human leukocytes under EB and MW exposure with/without the BL in the cell cultures are discussed.

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