Mathematics – Logic
Scientific paper
Oct 2007
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007oleb...37..357c&link_type=abstract
Origins of Life and Evolution of Biospheres, Volume 37, Issue 4-5, pp. 357-361
Mathematics
Logic
Macromolecular Sequences, Never Born Proteins, Phage Display, Prebiotic Synthesis, Random Polypeptides Fold, Thrombin Selection
Scientific paper
Starting from the statement that no reliable methods are known to produce high molecular weight polypeptides under prebiotic conditions, a possible approach, at least to understand the differences between extant proteins and the possible large number of never born proteins, could be biological. Using the phage display method a large library of totally random amino acidic sequences was obtained. Consequently, different experiments to directly consider the frequency of stable folds were performed, and the interesting results obtained from such new approach are discussed in terms of contingency, contributing to the discussion on the selection mechanism of extant proteins.
Chiarabelli Cristiano
de Lucrezia Davide
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