Question 3: The Problem of Macromolecular Sequences: The Forgotten Stumbling Block

Details Question 3: The Problem of Macromolecular Sequences: The Forgotten Stumbling Block Question 3: The Problem of Macromolecular Sequences: The Forgotten Stumbling Block

Oct 2007

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007oleb...37..363l&link_type=abstract

Origins of Life and Evolution of Biospheres, Volume 37, Issue 4-5, pp. 363-365

Physics

Copolymerization, Protein Sequence, Macromolecular Sequence, Folding, Amino Acid Condensation

Scientific paper

The Author agrees in principle with the question/statement, but states also that an important qualification is needed within this question. In fact, it is not possible by the bottom up approach to find the conditions for the synthesis of our actual proteins—lysozyme, chymotrypsin or the like—however it is possible to show experimentally that co-oligopeptides chains of that length can be produced by prebiotic reactions. Considering such a synthesis, it is important to recall that proteins—and nucleic acids—are not simply polymers, but are co-polymers, and the kinetics and thermodynamics attending the synthesis of copolymers poses stringent constraints for the biogenesis and growth of specific sequences. Such constraints are examined and discussed.

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