Question 1: Peptide Nucleic Acids and the Origin and Homochirality of Life

Details Question 1: Peptide Nucleic Acids and the Origin and Homochirality of Life Question 1: Peptide Nucleic Acids and the Origin and Homochirality of Life

Oct 2007

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007oleb...37..323n&link_type=abstract

Origins of Life and Evolution of Biospheres, Volume 37, Issue 4-5, pp. 323-328

Physics

2

Origin Of Life, Protocell, Homochirality, Peptide Nucleic Acid

Scientific paper

The possibilities of pseudo peptide DNA mimics like PNA (peptide nucleic acid) having a role for the prebiotic origin of life prior to an RNA world is discussed. In particular a scenario is proposed in which protocells with an achiral genetic material through several generations stepwise is converted into a chiral genetic material, e.g., by incorporation of RNA units. Provided that a sufficiently large sequence space is occupied, a selection process based on catalytic function in which a single cell (first common ancestor) has a definite evolutionary advantage, selection of this cell would by contingency also lock it into homochirality.

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