Physics – Biological Physics
Scientific paper
2009-02-27
Phys. Rev. E, 79 030901 (R) (2009)
Physics
Biological Physics
6 pages, 4 figures, to appear in Phys. Rev. E (R)
Scientific paper
10.1103/PhysRevE.79.030901
We discuss multiscale simulations of long biopolymer translocation through wide nanopores that can accommodate multiple polymer strands. The simulations provide clear evidence of folding quantization, namely, the translocation proceeds through multi-folded configurations characterized by a well-defined integer number of folds. As a consequence, the translocation time acquires a dependence on the average folding number, which results in a deviation from the single-exponent power-law characterizing single-file translocation through narrow pores. The mechanism of folding quantization allows polymers above a threshold length (approximately $1,000$ persistence lengths for double-stranded DNA) to exhibit cooperative behavior and as a result to translocate noticeably faster.
Bernaschi Massimo
Fyta Maria
Kaxiras Efthimios
Melchionna Simone
Succi Sauro
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