Protein sequence and structure: Is one more fundamental than the other?

Details Protein sequence and structure: Is one more fundamental than the other? Protein sequence and structure: Is one more fundamental than the other?

2012-04-12

arxiv.org/abs/1204.2725v1

Biology

Quantitative Biology

Biomolecules

7 pages, 4 figures, to appear in J. Stat. Phys

Scientific paper

10.1007/s10955-012-0456-3

We argue that protein native state structures reside in a novel "phase" of matter which confers on proteins their many amazing characteristics. This phase arises from the common features of all globular proteins and is characterized by a sequence-independent free energy landscape with relatively few low energy minima with funnel-like character. The choice of a sequence that fits well into one of these predetermined structures facilitates rapid and cooperative folding. Our model calculations show that this novel phase facilitates the formation of an efficient route for sequence design starting from random peptides.

Affiliated with

Also associated with

No associations

Rating

Protein sequence and structure: Is one more fundamental than the other? does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Protein sequence and structure: Is one more fundamental than the other?, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein sequence and structure: Is one more fundamental than the other? will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-312467