Protein micro patterned lattices to probe a fundamental lengthscale involved in cell adhesion

Details Protein micro patterned lattices to probe a fundamental lengthscale involved in cell adhesion Protein micro patterned lattices to probe a fundamental lengthscale involved in cell adhesion

2009-08-20

arxiv.org/abs/0908.2953v1

Physics

Biological Physics

submitted to Appl. Phys. Lett

Scientific paper

Cell adhesion, a fundamental process of cell biology is involved in the embryo development and in numerous pathologies especially those related to cancers. We constrained cells to adhere on extracellular matrix proteins patterned in a micro lattices. The actin cytoskeleton is particularly sensitive to this constraint and reproducibly self organizes in simple geometrical patterns. Such highly organized cells are functional and proliferate. We performed statistical analysis of spread cells morphologies and discuss the existence of a fundamental lengthscale associated with active processes required for spreading.

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