Protein folding in a force-clamp

Details Protein folding in a force-clamp Protein folding in a force-clamp

2006-03-17

arxiv.org/abs/q-bio/0603018v1

Biology

Quantitative Biology

Biomolecules

9 pages, 4 figures, Journal of Chemical Physics (in press)

Scientific paper

10.1063/1.2192768

Kinetics of folding of a protein held in a force-clamp are compared to an unconstrained folding. The comparison is made within a simple topology-based dynamical model of ubiquitin. We demonstrate that the experimentally observed variations in the end-to-end distance reflect microscopic events during folding. However, the folding scenarios in and out of the force-clamp are distinct.

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