Biology – Quantitative Biology – Biomolecules
Scientific paper
2009-06-13
Biology
Quantitative Biology
Biomolecules
18 pages
Scientific paper
The importance of torsion vibration in the transmission of life information is indicated. The localization of quantum torsion state is proved. Following these analyses a formalism on the quantum theory of conformation-electron system is proposed. The conformational-electronic transition is calculated by non-adiabatic operator method. The protein folding is viewed from conformational quantum transition and the folding rate is calculated. The time-scale of microsecond to millisecond for the fundamental folding event (nucleation, collapse, etc) is deduced. The dependence of transition rate W on N inertial moments is given. It indicates how W increases with the number N of torsion angles and decreases with the inertial moment I of atomic group in cooperative transition. The temperature dependence is also deduced which is different from chemical reaction in high-temperature region. It is demonstrated that the conformational dynamics gives deep insights into the folding mechanism and provides a useful tool for analyzing and explaining experimental facts on the rate of protein folding.
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