Presence of pKa Perturbations Among Homeodomain Residues Facilitates DNA Binding

Details Presence of pKa Perturbations Among Homeodomain Residues Facilitates DNA Binding Presence of pKa Perturbations Among Homeodomain Residues Facilitates DNA Binding

2009-07-28

arxiv.org/abs/0907.4819v1

Biology

Quantitative Biology

Biomolecules

Frenz, C.M. & Lefebvre, P.P. (2009) Presence of pKa Perturbations Among Homeodomain Residues Facilitates DNA Binding, Proceedi

Scientific paper

Homeodomain containing proteins are a broad class of DNA binding proteins that are believed to primarily function as transcription factors. Electrostatics interactions have been demonstrated to be critical for the binding of the homeodomain to DNA. An examination of the electrostatic state of homeodomain residues involved in DNA phosphate binding has demonstrated the conserved presence of upward shifted pKa values among the basic residue of lysine and arginine. It is believed that these pKa perturbations work to facilitate binding to DNA since they ensure that the basic residues always retain a positive charge.

Affiliated with

Also associated with

No associations

Rating

Presence of pKa Perturbations Among Homeodomain Residues Facilitates DNA Binding does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Presence of pKa Perturbations Among Homeodomain Residues Facilitates DNA Binding, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Presence of pKa Perturbations Among Homeodomain Residues Facilitates DNA Binding will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-681462