Presence of a low molecular weight endogenous inhibitor on 3H-muscimol binding in synaptic membranes

Physics

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

1

Scientific paper

The specific binding of 3H-muscimol to synaptic membrane preparations obtained from the rat brain has been thought to reflect the association of γ-aminobutyric acid (GABA), a potential candidate as an inhibitory neurotransmitter in the mammalian central nervous system (CNS), with its synaptic receptors1,2. Treatment of synaptic membranes with Triton X-100 significantly increases the specific binding of 3H-muscimol2. Several reports also indicate the presence of endogenous substances, such as GABA3, acidic protein4 and phosphatidylethanolamine5, which inhibit Na-independent binding of 3H-GABA in the synaptic membranous fractions from the rat brain. We report here that in the supernatant obtained from Triton-treated synaptic membranes there exists a new type of endogenous inhibitor of 3H-muscimol binding which is apparently different from the inhibitory substances described previously3-5. The new inhibitor has a low molecular weight (MW) and probably originated from neurones rather than glial cells. We have termed this endogenous inhibitor the GABA receptor binding inhibitory factor (GRIF).

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

Presence of a low molecular weight endogenous inhibitor on 3H-muscimol binding in synaptic membranes does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Presence of a low molecular weight endogenous inhibitor on 3H-muscimol binding in synaptic membranes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Presence of a low molecular weight endogenous inhibitor on 3H-muscimol binding in synaptic membranes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-1217770

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.