Predicting the Drug Release Kinetics of Matrix Tablets

Details Predicting the Drug Release Kinetics of Matrix Tablets Predicting the Drug Release Kinetics of Matrix Tablets

2008-10-29

arxiv.org/abs/0810.5323v3

Discr. Contin. Dyn. Sys. B 12(2):261-277 (2009)

Physics

Medical Physics

17 pages, 7 figures; Elaborated at the first Workshop on the Application of Mathematics to Problems in Biomedicine, December 1

Scientific paper

In this paper we develop two mathematical models to predict the release kinetics of a water soluble drug from a polymer/excipient matrix tablet. The first of our models consists of a random walk on a weighted graph, where the vertices of the graph represent particles of drug, excipient and polymer, respectively. The graph itself is the contact graph of a multidisperse random sphere packing. The second model describes the dissolution and the subsequent diffusion of the active drug out of a porous matrix using a system of partial differential equations. The predictions of both models show good qualitative agreement with experimental release curves. The models will provide tools for designing better controlled release devices.

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