Possible prebiotic catalysts formed from adenine and aldehyde

Details Possible prebiotic catalysts formed from adenine and aldehyde Possible prebiotic catalysts formed from adenine and aldehyde

Sep 2000

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2000p%26ss...48.1139v&link_type=abstract

Planetary and Space Science, Volume 48, Issue 11, p. 1139-1142.

Computer Science

1

Scientific paper

Careful examination of the present metabolism and in vitro selection of various catalytic RNAs strongly support the ``RNA World'' hypothesis of the origin of life. However, in this scenario, the difficult prebiotic synthesis of ribose and consequently of nucleotides remain a major problem. In order to overcome this problem and obtain nucleoside analogs, we are investigating reactions of the nucleic acid base, adenine /1, with different aldehydes under presumably prebiotic conditions. In the reaction of adenine and pyruvaldehyde /2 in water, we report here the formation in high yield of two isomeric products. These compounds possessing alcohols functions as nucleosides result from condensation of two molecules of pyruvaldehyde on the 6-amino group of one adenine molecule. Their catalytic activities in the model hydrolysis of /p-nitrophenylesters appeared interesting in the search of prebiotic catalysts.

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