polymerization on the Rocks: β-amino Acids and Arginine

Details polymerization on the Rocks: β-amino Acids and Arginine polymerization on the Rocks: β-amino Acids and Arginine

Jun 1998

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1998oleb...28..245l&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 28, Issue 3, p. 245-257 (1998).

Physics

9

Scientific paper

We have studied the accumulation of long oligomers of β-amino acids on the surface of minerals using the `polymerization on the rocks' protocol. We find that long oligopeptides of β-glutamic acid which cannot be formed in homogeneous aqueous solution are accumulated efficiently on the surface of hydroxylapatite using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC) as condensing agent. The EDAC-induced oligomerization of aspartic acid on hydroxylapatite proceeds even more efficiently. Hydroxylapatite can also facilitate the ligation of the tripeptide (glu)_3. The `polymerization on the rocks' scenario is not restricted to negatively-charged amino acids. Oligoarginines are accumulated on the surface of illite using carbonyldiimidizole (CDI) as condensing agent. We find that FeS_2 catalyzes the CDI-induced oligomerization of arginine, although it does not adsorb oligoarginines. These results are relevant to the formation of polypeptides on the primitive earth.

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