Biology – Quantitative Biology – Molecular Networks
Scientific paper
2011-05-22
Contemporary Physics Vol. 52, No. 5, 439-464 (2011)
Biology
Quantitative Biology
Molecular Networks
36 pages, 8 figures, 153 references, to be published in Contemporary Physics
Scientific paper
10.1080/00107514.2011.588432
Cellular behavior is governed by gene regulatory processes that are intrinsically dynamic and nonlinear, and are subject to non-negligible amounts of random fluctuations. Such conditions are ubiquitous in physical systems, where they have been studied for decades using the tools of statistical and nonlinear physics. The goal of this review is to show how approaches traditionally used in physics can help in reaching a systems-level understanding of living cells. To that end, we present an overview of the dynamical phenomena exhibited by genetic circuits and their functional significance. We also describe the theoretical and experimental approaches that are being used to unravel the relationship between circuit structure and function in dynamical cellular processes under the influence of noise, both at the single-cell level and in cellular populations, where intercellular coupling plays an important role.
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