Phase diagram of a ternary mixture of cholesterol and saturated and unsaturated lipids calculated from a microscopic model

Details Phase diagram of a ternary mixture of cholesterol and saturated and unsaturated lipids calculated from a microscopic model Phase diagram of a ternary mixture of cholesterol and saturated and unsaturated lipids calculated from a microscopic model

2005-08-01

arxiv.org/abs/physics/0508011v1

Published in Physical Review Letters, 96, 098101 (2006).

Physics

Biological Physics

9 pages, 3 figures. Submitted to Physical Review Letters

Scientific paper

10.1103/PhysRevLett.96.098101

We employ a molecular model to study a ternary mixture of saturated lipid, with tails of sixteen carbons, a mono unsaturated lipid with tails of eighteen carbons, and cholesterol. The model, solved within mean-field theory, produces several forms of phase diagrams depending upon the relative strengths of interactions, but only one that shows the coexistence of two liquid phases observed in experiment. The lipids in the phase rich in cholesterol are more ordered than those in the other. The binary cholesterol, saturated lipid system also exhibits liquid, liquid coexistence.

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