Peptide size dependent active transport in the proteasome

Details Peptide size dependent active transport in the proteasome Peptide size dependent active transport in the proteasome

2003-11-26

arxiv.org/abs/q-bio/0311036v2

Biology

Quantitative Biology

Biomolecules

4 pages, 4 figures

Scientific paper

We investigate the transport of proteins inside the proteasome and propose an active transport mechanism based on a spatially asymmetric interaction potential of peptide chains. The transport is driven by fluctuations which are always present in such systems. We compute the peptide-size dependent transport rate which is essential for the functioning of the proteasome. In agreement with recent experiments, varying temperature changes the transport mechanism qualitatively.

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