Physics
Scientific paper
Jul 1996
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1996aipc..379...55n&link_type=abstract
Physical orgin of homochirality in life. AIP Conference Proceedings, Volume 379, pp. 55-64 (1996).
Physics
Structure And Bonding, Macromolecules And Polymer Molecules
Scientific paper
PNA is a pseudopeptide DNA mimic in which the natural nucleobases have been retained, but the backbone consists of N-(2-aminoethyl)glycine units to which the nucleobases are attached via methylene carbonyl linkers. The finding that PNA forms Warson-Crick-like helices with complementary DNA, RNA or PNA combined with the fact PNA is held together by amide bonds has made PNA of interest as a model for a primordial genetic material. Furthermore, the PNA backbone is achiral, while preferred chirality can be induced in PNA-PNA double helices by attached chiral ligands, thereby providing a new way of ``chiral amplification.'' Finally, it has been demonstrated that PNA-template directed synthesis of RNA and PNA is feasible.
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