Physics – Biological Physics
Scientific paper
2010-08-05
Proc Natl Acad Sci U S A. 1999 August 31; 96(18): 10140-10145
Physics
Biological Physics
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC17856/ http://www.pnas.org/content/96/18/10140.full.pdf
Scientific paper
Gradual disruption of the actin cytoskeleton induces a series of structural shape changes in cells leading to a transformation of cylindrical cell extensions into a periodic chain of "pearls". Quantitative measurements of the pearling instability give a square-root behavior for the wavelength as a function of drug concentration. We present a theory that explains these observations in terms of the interplay between rigidity of the submembranous actin shell and tension that is induced by boundary conditions set by adhesion points. The theory allows estimation of the rigidity and thickness of this supporting shell. The same theoretical considerations explain the shape of nonadherent edges in the general case of untreated cells.
Bar-Ziv Roy
Bershadsky Alexander
Moses Elisha
Safran Samuel A.
Tlusty Tsvi
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