Parameter estimation for Boolean models of biological networks

Details Parameter estimation for Boolean models of biological networks Parameter estimation for Boolean models of biological networks

2009-08-21

arxiv.org/abs/0908.3037v1

Biology

Quantitative Biology

Molecular Networks

Web interface of the software is available at http://polymath.vbi.vt.edu/polynome/

Scientific paper

10.1016/j.tcs.2010.04.034

Boolean networks have long been used as models of molecular networks and play an increasingly important role in systems biology. This paper describes a software package, Polynome, offered as a web service, that helps users construct Boolean network models based on experimental data and biological input. The key feature is a discrete analog of parameter estimation for continuous models. With only experimental data as input, the software can be used as a tool for reverse-engineering of Boolean network models from experimental time course data.

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