Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation

Details Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation Origin of genetically encoded protein synthesis: A model based on selection for RNA peptidation

May 1991

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1991oleb...21..165w&link_type=abstract

Origins of Life and Evolution of the Biosphere, Volume 21, Issue 3, pp.165-176

Physics

5

Scientific paper

The difficulty in explaining the origin of genetic coding centres on the need to identify selective advantages that could account for the synthesis of peptidyl-tRNA, the essential intermediate in genetically programmed translation. It is resolved by a recognition of the functional advantages derivable from the post-transcriptional addition of peptide cofactors to RNA apo-catalysts. This enables the formulation of a theory for the origin of the genetic encoding of protein synthesis by RNA.

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