Optimal Path to Epigenetic Switching

Details Optimal Path to Epigenetic Switching Optimal Path to Epigenetic Switching

2004-06-03

arxiv.org/abs/q-bio/0406008v3

Biology

Quantitative Biology

Molecular Networks

5 pages. 2 figures, uses revtex 4. PR-E reviewed for publication

Scientific paper

We use large deviation methods to calculate rates of noise-induced
transitions between states in multistable genetic networks. We analyze a
synthetic biochemical circuit, the toggle switch, and compare the results to
those obtained from a numerical solution of the master equation.

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