Optimal experimental design in an EGFR signaling and down-regulation model

Details Optimal experimental design in an EGFR signaling and down-regulation model Optimal experimental design in an EGFR signaling and down-regulation model

2006-10-12

arxiv.org/abs/q-bio/0610024v1

Biology

Quantitative Biology

Molecular Networks

13 pages, 9 figures in main text. 7 pages, 7 figures in supplementary material. Submitted to IEE Proceedings Systems Biology

Scientific paper

We apply the methods of optimal experimental design to a differential equation model for epidermal growth factor receptor (EGFR) signaling, trafficking, and down-regulation. The model incorporates the role of a recently discovered protein complex made up of the E3 ubiquitin ligase, Cbl, the guanine exchange factor (GEF), Cool-1 (Beta-Pix), and the Rho family G protein Cdc42. The complex has been suggested to be important in disrupting receptor down-regulation. We demonstrate that the model interactions can accurately reproduce the experimental observations, that they can be used to make predictions with accompanying uncertainties, and that we can apply ideas of optimal experimental design to suggest new experiments that reduce the uncertainty on unmeasurable components of the system.

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