Optical Marking of Alcohol Induced Hemoglobin Modification

Physics – Biological Physics

Scientific paper

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34 pages, 5 figures, 4 tables. submitted to the Journal of Biomedical Optics

Scientific paper

It has been shown that conformational modifications of Hb induced by ethanol consumption can be visualized in optical spectra studying oxygenation kinetics of hemoglobin or mixing hemoglobin with Cibacron blue dye. Better dye affinity of blood proteins extracted from alcoholised rats with respect to those from non-alcoholised ones confirms that ethanol and its metabolites induce structural pathologies in blood protein molecules. The detected changes for the case of the posterity of intoxicated animals may be explained as a post-translation modification, as well as a disturbance of the structure and function of tissue cellular gene mechanism for the blood creation. It is established that alcohol intake during first four months leads to the decrease of fractional weight of oxyhemoglobin and to the increase of methemoglobin amount in blood. Further alcohol consumption is accompanied by recovering of the normal level of hemoglobin derivatives in blood. Normalization of the fractional weight of hemoglobin derivatives in blood after durable (longer than 5-6 months) ethanol intoxication is most probably due to the activation of the enzyme (acetaldehyde dehydrogenase) system, lowering the level of acetaldehydes in blood.

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