One Hub-One Process: A Tool Based View on Regulatory Network Topology

Biology – Quantitative Biology – Molecular Networks

Scientific paper

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

18 pages, 3 figures, 5 supplementary figures

Scientific paper

10.1186/1752-0509-2-25

The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based localization on molecular networks. To quantify structure-function relationship we investigate similarities of proteins which are close in the regulatory network of the yeast Saccharomyces Cerevisiae. We find that the topology of the regulatory network show weak remnants of its history of network reorganizations, but strong features of co-regulated proteins associated to similar tasks. This suggests that local topological features of regulatory networks, including broad degree distributions, emerge as an implicit result of matching a number of needed processes to a finite toolbox of proteins.

No associations

LandOfFree

Say what you really think

Search LandOfFree.com for scientists and scientific papers. Rate them and share your experience with other people.

Rating

One Hub-One Process: A Tool Based View on Regulatory Network Topology does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with One Hub-One Process: A Tool Based View on Regulatory Network Topology, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and One Hub-One Process: A Tool Based View on Regulatory Network Topology will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFWR-SCP-O-531106

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.