Biology – Quantitative Biology – Molecular Networks
Scientific paper
2007-11-14
BMC Systems Biology 2008, 2:25
Biology
Quantitative Biology
Molecular Networks
18 pages, 3 figures, 5 supplementary figures
Scientific paper
10.1186/1752-0509-2-25
The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based localization on molecular networks. To quantify structure-function relationship we investigate similarities of proteins which are close in the regulatory network of the yeast Saccharomyces Cerevisiae. We find that the topology of the regulatory network show weak remnants of its history of network reorganizations, but strong features of co-regulated proteins associated to similar tasks. This suggests that local topological features of regulatory networks, including broad degree distributions, emerge as an implicit result of matching a number of needed processes to a finite toolbox of proteins.
Axelsen Jacob Bock
Bernhardsson Sebastian
Sneppen Kim
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