Nuclear medical imaging using β+γ coincidences from 44Sc radio-nuclide with liquid xenon as detection medium

Details Nuclear medical imaging using β+γ coincidences from 44Sc radio-nuclide with liquid xenon as detection medium Nuclear medical imaging using β+γ coincidences from 44Sc radio-nuclide with liquid xenon as detection medium

Feb 2007

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2007nimpa.571..142g&link_type=abstract

Nuclear Instruments and Methods in Physics Research Section A, Volume 571, Issue 1-2, p. 142-145.

Physics

10

Scintillation Detectors, Dielectric Properties Of Solids And Liquids, Positron Emission Tomography, X- And Gamma-Ray Telescopes And Instrumentation

Scientific paper

We report on a new nuclear medical imaging technique based on the measurement of the emitter location in the three dimensions with a few mm spatial resolution using β+γ emitters. Such measurement could be realized thanks to a new kind of radio-nuclides which emit a γ-ray quasi-simultaneously with the β+ decay. The most interesting radio-nuclide candidate, namely 44Sc, will be potentially produced at the Nantes cyclotron ARRONAX. The principle is to reconstruct the intersection of the classical line of response (obtained with a standard PET camera) with the direction cone defined by the third γ-ray. The emission angle measurement of this additional γ-ray involves the use of a Compton telescope for which a new generation of camera based on a liquid xenon (LXe) time projection chamber is considered. GEANT3 simulations of a large acceptance LXe Compton telescope combined with a commercial micro-PET (LSO crystals) have been performed and the obtained results will be presented. They demonstrate that a good image can be obtained from the accumulation of each three-dimensional measured position. A spatial resolution of 2.3 mm has been reached with an injected activity of 0.5 MBq for a 44Sc point source emitter.

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