Nonlinear Relaxation Dynamics in Elastic Networks and Design Principles of Molecular Machines

Details Nonlinear Relaxation Dynamics in Elastic Networks and Design Principles of Molecular Machines Nonlinear Relaxation Dynamics in Elastic Networks and Design Principles of Molecular Machines

2007-05-17

arxiv.org/abs/0705.2504v1

Proc. Natl. Acad. Sci. (USA) 104, 8697 (2007)

Biology

Quantitative Biology

Biomolecules

12 pages, 9 figures

Scientific paper

10.1073/pnas.0702950104

Analyzing nonlinear conformational relaxation dynamics in elastic networks corresponding to two classical motor proteins, we find that they respond by well-defined internal mechanical motions to various initial deformations and that these motions are robust against external perturbations. We show that this behavior is not characteristic for random elastic networks. However, special network architectures with such properties can be designed by evolutionary optimization methods. Using them, an example of an artificial elastic network, operating as a cyclic machine powered by ligand binding, is constructed.

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