Non-equilibrium dynamics of gene expression and the Jarzynski equality

Details Non-equilibrium dynamics of gene expression and the Jarzynski equality Non-equilibrium dynamics of gene expression and the Jarzynski equality

2007-12-03

arxiv.org/abs/0712.0170v1

Biology

Quantitative Biology

Molecular Networks

Scientific paper

10.1103/PhysRevLett.100.188101

In order to express specific genes at the right time, the transcription of genes is regulated by the presence and absence of transcription factor molecules. With transcription factor concentrations undergoing constant changes, gene transcription takes place out of equilibrium. In this paper we discuss a simple mapping between dynamic models of gene expression and stochastic systems driven out of equilibrium. Using this mapping, results of nonequilibrium statistical mechanics such as the Jarzynski equality and the fluctuation theorem are demonstrated for gene expression dynamics. Applications of this approach include the determination of regulatory interactions between genes from experimental gene expression data.

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