Physics – Biological Physics
Scientific paper
2010-08-31
Eur. Phys. J. Special Topics 187, 171 (2010)
Physics
Biological Physics
To appear in EPJST
Scientific paper
10.1140/epjst/e2010-01281-4
Noisy saltatory spike propagation along myelinated axons is studied within a stochastic Hodgkin-Huxley model. The intrinsic noise (whose strength is inverse proportional to the nodal membrane size) arising from fluctuations of the number of open ion channels influences the dynamics of the membrane potential in a node of Ranvier where the sodium ion channels are predominantly localized. The nodes of Ranvier are linearly coupled. As the measure for the signal propagation reliability we focus on the ratio between the number of initiated spikes and the transmitted spikes. This work supplements our earlier study [A. Ochab-Marcinek, G. Schmid, I. Goychuk and P. H\"anggi, Phys. Rev E 79, 011904 (2009)] towards stronger channel noise intensity and supra-threshold coupling. For strong supra-threshold coupling the transmission reliability decreases with increasing channel noise level until the causal relationship is completely lost and a breakdown of the spike propagation due to the intrinsic noise is observed.
Hänggi Peter
Li Yunyun
Schmid Gerhard
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