Noise enhanced persistence in a biochemical regulatory network with feedback control

Details Noise enhanced persistence in a biochemical regulatory network with feedback control Noise enhanced persistence in a biochemical regulatory network with feedback control

2007-09-22

arxiv.org/abs/0709.3606v2

Biology

Quantitative Biology

Molecular Networks

4 pages, 4 figures, submitted for publication

Scientific paper

10.1103/PhysRevLett.100.058105

We find that discrete noise of inhibiting (signal) molecules can greatly delay the extinction of plasmids in a plasmid replication system: a prototypical biochemical regulatory network. We calculate the probability distribution of the metastable state of the plasmids and show on this example that the reaction rate equations may fail in predicting the average number of regulated molecules even when this number is large, and the time is much shorter than the mean extinction time.

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