Networks of motifs from sequences of symbols

Details Networks of motifs from sequences of symbols Networks of motifs from sequences of symbols

2010-02-03

arxiv.org/abs/1002.0668v2

Phys. Rev. Lett. 105, 178702 (2010)

Biology

Quantitative Biology

Molecular Networks

Accepted for publication in Phys. Rev. Lett. Main article 4 pages, 2 figure; supplementary material 4 pages, 1 figure

Scientific paper

10.1103/PhysRevLett.105.178702

We introduce a method to convert an ensemble of sequences of symbols into a weighted directed network whose nodes are motifs, while the directed links and their weights are defined from statistically significant co-occurences of two motifs in the same sequence. The analysis of communities of networks of motifs is shown to be able to correlate sequences with functions in the human proteome database, to detect hot topics from online social dialogs, to characterize trajectories of dynamical systems, and might find other useful applications to process large amount of data in various fields.

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