Negative Pressures in Knee Joints

Physics

Scientific paper

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Scientific paper

GUYTON1,2 established the concept of a negative interstitial tissue pressure, and observations which I have made on the knee joints of rabbits, cats, dogs and man have supported this idea. One hundred and sixty-eight observations were made on normal knees, thirty-six in cats, thirty in rabbits, ninety-two in dogs and ten in man. The pressure was found to be between -2 and -10 mm of mercury in no less than 165 of these observations; the exceptions were one cat where a pressure of -14 mm of mercury was found-though the contralateral knee had a pressure of -7.5 mm of mercury-and one cat and one dog both of which had a pressure of +1 mm of mercury-though there was no detectable clinical effusion.

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