Nanoscale field effect transistor for biomolecular signal amplification

Details Nanoscale field effect transistor for biomolecular signal amplification Nanoscale field effect transistor for biomolecular signal amplification

2008-02-13

arxiv.org/abs/0802.1756v1

APPLIED PHYSICS LETTERS 91, 243511 (2007)

Physics

Biological Physics

4 pages, 3 figures, two-column format. Related papers can be found at http://nano.bu.edu

Scientific paper

10.1063/1.2822445

We report amplification of biomolecular recognition signal in lithographically defined silicon nanochannel devices. The devices are configured as field effect transistors (FET) in the reversed source-drain bias region. The measurement of the differential conductance of the nanowire channels in the FET allows sensitive detection of changes in the surface potential due to biomolecular binding. Narrower silicon channels demonstrate higher sensitivity to binding due to increased surface-to-volume ratio. The operation of the device in the negative source-drain region demonstrates signal amplification. The equivalence between protein binding and change in the surface potential is described.

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