Nano-scale mechanical probing of supported lipid bilayers with atomic force microscopy

Details Nano-scale mechanical probing of supported lipid bilayers with atomic force microscopy Nano-scale mechanical probing of supported lipid bilayers with atomic force microscopy

2010-06-20

arxiv.org/abs/1006.3937v2

Phys. Rev. E 82, 041920 (2010) [6 pages]

Physics

Biological Physics

6 pages, 6 figures, accepted for publication in Physical Review E

Scientific paper

10.1103/PhysRevE.82.041920

We present theory and experiments for the force-distance curve $F(z_0)$ of an atomic force microscope (AFM) tip (radius $R$) indenting a supported fluid bilayer (thickness $2d$). For realistic conditions the force is dominated by the area compressibility modulus $\kappa_A$ of the bilayer, and, to an excellent approximation, given by $F= \pi \kappa_A R z_0^2/(2d-z_0)^2$. The experimental AFM force curves from coexisting liquid ordered and liquid disordered domains in 3-component lipid bilayers are well-described by our model, and provides $\kappa_A$ in agreement with literature values. The liquid ordered phase has a yield like response that we model by hydrogen bond breaking.

Affiliated with

Also associated with

No associations

Rating

Nano-scale mechanical probing of supported lipid bilayers with atomic force microscopy does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Nano-scale mechanical probing of supported lipid bilayers with atomic force microscopy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nano-scale mechanical probing of supported lipid bilayers with atomic force microscopy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-186127