Mathematics – Logic
Scientific paper
Aug 1992
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1992adspr..12..393t&link_type=abstract
Advances in Space Research, Volume 12, Issue 2-3, p. 393-401.
Mathematics
Logic
Scientific paper
Relative Biological Effectiveness (RBE) and Quality Factor (Q) at extreme values of Linear Energy Transfer (LET) have been determined on the basis of experiments with single-cell systems and specific tissue responses. In typical single cell systems, each heavy particle (Ar or Fe) passes through a single cell or no cell. In tissue end-point experiments each heavy particle passes through several cells, and the LET can exceed 200 keV/μm in every cell. In most laboratory animal tissue systems, however, only a small portion of the hit cells are capable of expressing the end-point of interest to the investigator, such as cell killing, mutation or carcinogenesis. The following question must therefore be addressed: Do RBE's and Q factors derived from single-cell experiments properly account for the increased probability of multiple-cell damage by HZE tracks? A model is offered in which measured radiation effects and known tissue properties are combined to estimate the value of a multiplier of damage effectiveness on the basis of number of cells at risk, p3n, per track containing a hit cell, where n is the number of cells per track, based on tissue and organ geometry, and p3 is the probability that a cell in the track is capable of expressing the experimental end-point.
No associations
LandOfFree
Multiple cell hits by particle tracks in solid tissues does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Multiple cell hits by particle tracks in solid tissues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multiple cell hits by particle tracks in solid tissues will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-1165030